When's the last time you saw a music video open with David Arquette? I didn't understand why at first, and then I realized where this song was used! This is Creed's "What If" from their first album Human Clay. It's said to be one of the heaviest creed songs, and was used on the soundtrack for the movie Scream 3. Creed would actually produce the entire album for that movie!
Also Scott Stapp sings the title of the song 53 times.
Creed - What If - 2000